


2018-01-23
NOSLEN SUAREZ
NOSLEN SUAREZ

2018-02-22
VALERIA RODRÍGUEZ-FAJARDO
VALERIA RODRÍGUEZ-FAJARDO

2018-02-26
BENJAMIN WOLTER
BENJAMIN WOLTER

2018-03-19
JOANNA ZIELINSKA
JOANNA ZIELINSKA

2018-03-23
QUAN LIU
QUAN LIU

2018-03-28
LARA LAPARRA
LARA LAPARRA

2018-04-03
GUILLAUME CORDIER
GUILLAUME CORDIER

2018-05-22
KEVIN SCHÄDLER
KEVIN SCHÄDLER

2018-06-14
MIRIAM MARCHENA
MIRIAM MARCHENA

2018-06-19
CARLOS ABELLAN
CARLOS ABELLAN

2018-07-02
LUKAS NEUMEIER
LUKAS NEUMEIER

2018-07-24
SHAHRZAD PARSA
SHAHRZAD PARSA

2018-07-25
PAU FARRERA
PAU FARRERA

2018-07-31
BARBARA BUADES
BARBARA BUADES

2018-09-06
SIMON COOP
SIMON COOP

2018-09-13
NICOLAS MARING
NICOLAS MARING

2018-09-19
IVAN SUPIC
IVAN SUPIC

2018-10-02
ANIELLO LAMPO
ANIELLO LAMPO

2018-10-10
CÉSAR CABRERA
CÉSAR CABRERA

2018-10-11
FLORIAN CURCHOD
FLORIAN CURCHOD

2018-10-18
JOSEP CANALS
JOSEP CANALS

2018-10-19
ROLAND TERBORG
ROLAND TERBORG

2018-10-22
KAVITHA KALAVOOR
KAVITHA KALAVOOR

2018-10-24
MIGUEL MIRELES
MIGUEL MIRELES

2018-10-26
KYRA BORGMAN
KYRA BORGMAN

2018-10-30
JOSE M. GARCIA-GUIRADO
JOSE M. GARCIA-GUIRADO

2018-11-12
JIL SCHWENDER
JIL SCHWENDER

2018-12-10
JOSÉ RAMÓN MARTÍNEZ
JOSÉ RAMÓN MARTÍNEZ

2018-12-12
LIJUN MENG
LIJUN MENG

2018-12-17
NICOLÁS MORELL
NICOLÁS MORELL

2018-12-18
JUNXIONG WEI
JUNXIONG WEI
New Lab-on-a-Chip Strategies for Enantio-Selective and Non-Diffusion-Limited Biosensing

JOSE M. GARCIA-GUIRADO
October 30th, 2018
JOSE M. GARCIA-GUIRADO
Plasmon Nano-Optics
ICFO-The Institute of Photonic Sciences
The race for fast and small that drives nowadays society has also reached the field of biosensing. Looking for efficient and cost effective biosensors for applications including screening and treatment monitoring, biomolecular engineering, drug design and food industry; plasmonics and microfluidics technologies have synergistically grown to offer the most attractive solutions. The recent progress in nano-optics has paved the route toward the development of highly sensitive and label-free optical transducers using the localized surface plasmon resonance (LSPR). Additionally, LSPR offer high-end miniaturization and high degree of tunability of both sensors’ spatial and spectral responses. These unique properties have recently been interfaced with microfluidics towards lab-on-a-chip (LOC) functional platforms which offer reduced sample volumes and multi-tasking operations on a single chip.
Combining nano-optics, microfluidics and biochemical sensing makes this PhD project highly multidisciplinary. This blend aims at pushing the limits of LSPR sensing by addressing two significant problems in the biosensing community. On one hand, we went through chiral plasmonic sensing. Chiral molecules exhibit signatures in the ultraviolet frequency region. They are typically characterized by circular dichroism (CD), which suffers of low sensitivity and the need of big sample volumes and concentrations. Plasmonic nanostructures have the potential to enhance the sensitivity of chiral detection and translate the molecular signatures to the visible spectral range. However, to date, it remains unclear which properties plasmonic sensors should exhibit to maximize this effect and apply it to reliable enantiomer discrimination. As a consequence, a collection of results of difficult interpretation and cross comparison can be found in the literature. Here, we bring further insight into this complex problem and present a chiral plasmonic sensor composed of a racemic mixture of gammadions that enables us to directly differentiate enantiomers. We also present a plasmo-fluidic sensing platform, which allows the systematic study of chiral biomolecules by enabling multiple sensing assays on a single chip.
On the other hand, we addressed one of the major challenges of plasmonic sensing in microfluidics environments; the transport of the analyte to the sensor surface, which due to the laminar flow that rules in micro-channels, is limited by Brownian diffusion. Hence, dictates the total duration of the sensing assay. Here, we use the electrothermoplasmonic (ETP) effect to overcome this limit through opto-electrical fluid convective flow generation. To this end, we designed a LSPR sensing chip that integrates ETP operation into state-of-the-art microfluidics. Our results demonstrate that ETP-LSPR has improved performances over standard LSPR.
Tuesday October 30, 11:00. ICFO Auditorium
Thesis Advisor: Prof Dr Romain Quidant
ICFO-The Institute of Photonic Sciences
The race for fast and small that drives nowadays society has also reached the field of biosensing. Looking for efficient and cost effective biosensors for applications including screening and treatment monitoring, biomolecular engineering, drug design and food industry; plasmonics and microfluidics technologies have synergistically grown to offer the most attractive solutions. The recent progress in nano-optics has paved the route toward the development of highly sensitive and label-free optical transducers using the localized surface plasmon resonance (LSPR). Additionally, LSPR offer high-end miniaturization and high degree of tunability of both sensors’ spatial and spectral responses. These unique properties have recently been interfaced with microfluidics towards lab-on-a-chip (LOC) functional platforms which offer reduced sample volumes and multi-tasking operations on a single chip.
Combining nano-optics, microfluidics and biochemical sensing makes this PhD project highly multidisciplinary. This blend aims at pushing the limits of LSPR sensing by addressing two significant problems in the biosensing community. On one hand, we went through chiral plasmonic sensing. Chiral molecules exhibit signatures in the ultraviolet frequency region. They are typically characterized by circular dichroism (CD), which suffers of low sensitivity and the need of big sample volumes and concentrations. Plasmonic nanostructures have the potential to enhance the sensitivity of chiral detection and translate the molecular signatures to the visible spectral range. However, to date, it remains unclear which properties plasmonic sensors should exhibit to maximize this effect and apply it to reliable enantiomer discrimination. As a consequence, a collection of results of difficult interpretation and cross comparison can be found in the literature. Here, we bring further insight into this complex problem and present a chiral plasmonic sensor composed of a racemic mixture of gammadions that enables us to directly differentiate enantiomers. We also present a plasmo-fluidic sensing platform, which allows the systematic study of chiral biomolecules by enabling multiple sensing assays on a single chip.
On the other hand, we addressed one of the major challenges of plasmonic sensing in microfluidics environments; the transport of the analyte to the sensor surface, which due to the laminar flow that rules in micro-channels, is limited by Brownian diffusion. Hence, dictates the total duration of the sensing assay. Here, we use the electrothermoplasmonic (ETP) effect to overcome this limit through opto-electrical fluid convective flow generation. To this end, we designed a LSPR sensing chip that integrates ETP operation into state-of-the-art microfluidics. Our results demonstrate that ETP-LSPR has improved performances over standard LSPR.
Tuesday October 30, 11:00. ICFO Auditorium
Thesis Advisor: Prof Dr Romain Quidant