Evolutionary Self-Organisation: Lessons from the Polarisation Machinery in Budding Yeast

Liedewij Laan
February 25th, 2019 LIEDEWIJ LAAN Kavli Institute of NanoScience
Delft University

In this talk I will present our work on how the biochemical networks underlying cellular functions evolve. The biochemical network we focus on is the polarisation machinery in budding yeast, which establishes a polarized protein pattern on the cell membrane and is essential for proliferation. We combine bioinformatics, experimental evolution, quantitative cell biology and reaction-diffusion based modelling to understand how proteins that are essential for polarity establishment in one species can be absent in a closely related species or strain, while both species have the same functional requirement. So, how can these biochemical networks reorganize during evolution without significantly compromising fitness along the way?


11:30 Seminar
12:15 Meet the speaker – A discussion around Women in Science

This seminar is part of the BIST Master of Multidisciplinary Research in Experimental Sciences program. After the scientific seminar, there will be a Q&A “meet the speaker” session within the ICFO Woman for Science Month agenda. Prof. Laan will address questions related to women in scientific careers, with references from her own experience as a female researchers in a leading international institute in the Netherlands.

All ICFOnians are greatly encouraged to participate in both the scientific seminar and the Q&A session that will follow.

Women for Science Month agenda