Correlation Spectroscopies for Monitoring Cerebral Blood Flow
June 21st, 2019 ARJUN YODH University of Pennsylvania

The spatial and temporal intensity fluctuations of light scattered by tissue are sensitive to the motions tissue constituents such as red blood cells. This concept has proved valuable for probing blood flow tissues over a wide range of sizes using both single- and multiply-scattered light. I will start with basic ideas of fluctuation spectroscopy and show how they lead to the diffuse correlation spectroscopy monitoring technique, which employs the fluctuations of diffusing light to quantify cerebral blood flow non-invasively. This approach provides access to the blood flow biomarker and, when combined with various forms of fNIRS instrumentation, permits investigation of oxygen metabolism and autoregulation. In this discussion, I will delineate challenges that are intrinsic to the methodology, as well as some technical advances on the horizon that can help ameliorate these limitations. Finally, I will describe some recent cerebral monitoring applications which we have been exploring at Penn in both pre-clinical work and in measurements at the bedside in the neuro-intensive-care units at the Hospital of the University of Pennsylvania (HUP) and The Children’s Hospital of Philadephia (CHOP). Among these, for example, are flow-oxygenation-metabolism-autoregulation measurements during surgeries, during management of stroke/TBI patients and in healthy subjects, and during treatment (broadly defined). This work and the research of others illustrate the potential of the correlation spectroscopies for clinical and neuroscience applications in the future.

Seminar, June 21, 2019, 12:00. ICFO’s Seminar Room

Hosted by Prof. Turgut Durduran