
SLN - Team Loza
Dr. Pablo Loza-Alvarez
- Activities:
We conduct research and development at the cutting-edge of several microscopy and super resolution imaging techniques. We combine different technologies to make them compatible in a multimodal imaging fashion. Research activities include beam engineering, wavefront control and integration of novel light sources with different beam or pulse parameters. We study novel (endogenous and exogenous) contrast agents and new clearing methodologies to be applied to a wide variety of biomedical samples and imaging regimes. We also design novel algorithms for image quantification and analysis. Finally, our research involves optical manipulation tools such as Optical Tweezers and Femtosecond nanosurgery.
The group has well-equipped, modern laboratories for imaging inmicroscopy and super resolution.
- Available Resources:
- A 3 colour, 3D, gated STED microscope
- A STED CW microscope, operating also as a multiphoton (TPEF, SHG).
- A confocal microscope operating also as a multiphoton (TPEF, SHG, PSHG, THG).
- A custom made multiphoton microscope system (TPEF, SHG, PSHG, THG).
- Light Sheet Microscopes (3):
- high resolution
- high throughput
- ultramicroscope
- A Raman microscope.
- A custom made Raman microscope.
- A custom made Adaptive Optics Scanning Laser Ophthalmoscope
- Research Topics:
- Super Resolution Imaging
- Light Sheet Fluorescence Microscopy
- Raman Microscopy
- Multiphoton And Confocal Microscopy
- Collaborations:
- Corinne Lorenzo, ITAV
- Jordi Monés, Institut de la Màcula
- Edik Rafailov, Aston University
- Fariba Behbod, University of Kansas Medical Center
- Roser González, Universitat de Barcelona
- Pablo Villoslada, IDIBAPS
- Albert Lleó, Hospital de la Santa Creu i Sant Pau
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.
SLN - Team Loza
Dr. Pablo Loza-Alvarez


- Team Leader
- Dr. Pablo Loza-Alvarez
- Postdoctoral Researchers
- Dr. Gustavo Castro
- Dr. Enrico Castroflorio
- Javier Morgado Brajones
- Dr. Claudia P. Valdés E.
- Research Engineers
- Dr. Clara Vilches Caubet
- Visiting Scientists
- Dr. Emilio J. Gualda
- Dr. David Merino Arranz
- Dr. Jesús Planagumà i Valls
- Staff Research Engineers
- Dr. Jordi Andilla
- Dr. Mónica Marro Sánchez
- Former Group Members
- César Ricardo Alonso, Bio lab technician
- Iván Amat, PhD student
- David Artigas, Staff scientist
- Cuauhtemoc Araujo, Postdoctoral researcher
- Remy Ávila, Postdoctoral researcher
- Rodrigo Amador Avilés, PhD student
- Diego Di Battista, Visiting PhD student
- Marymar Becerra, Visiting PhD student
- Iain Cormack, Postdoctoral researcher
- Nela Durisic, Visiting scientist
- Sunil Kumar Girthar, Research fellow
- Luz del Carmen Gómez, Visiting student
- Raphaël Jorand, Visiting scientist
- Leszek Kaczmarek, Visiting scientist
- Laurent Ladepeche, Postdoctoral researcher
- Jacob Licea, Postdoctoral researcher
- Meropi Mari, Visiting scientist
- Erwin Martí, Visiting student
- Manoj Vathalloor Mathew, PhD student
- Norma Medina, Visiting PhD student
- David Merino, Research fellow
- Emilia Margarita Méndez, Visiting scientist
- Omar Olarte, PhD student
- Jason Otterstrom, Postdoctoral researcher
- Jonathan Palero, Postdoctoral researcher
- Omar Palillero, Visiting scientist
- Rafael Juliene Ant. Porcar, Research engineer
- Sotiris Psilodimitrakopoulos, Research engineer
- Mireya Elizabeth Ramírez, Visiting scientist
- Israel Rocha-Mendoza, Visiting scientist
- Oumaima Sliti, Postdoctoral researcher
- Silvia Soria, Postdoctoral researcher
- Elisa Tamariz, Visiting scientist
- Anisha Thayil K. Nair, PhD student
- Enric Viñas, Research engineer
- César Augusto Valadés, PhD student
SLN - Team Loza
Dr. Pablo Loza-Alvarez

- Regular Papers
- Tomato and melon meloidogyne resistant rootstocks improve crop yield but melon fruit quality is influenced by the cropping season Front. Plant Sci. 11, 560024 (2020)
- The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior Science 370, eaba2644 (2020) Highlighted in Science
- 3D and 4D image fusion: coping with differences in spectroscopic modes among hyperspectral images Anal. Chem. 92 (2020)
- Engineering polar oxynitrides: hexagonal perovskite BaWON2 Angew. Chem. 132, (2020)
- Bacillus firmus strain I-1582, a nematode antagonist by itself and through the plant Front. Plant Sci. 11, 796 (2020)
- Parallel array with axially coded light-sheet microscope Light-Sci. Appl. 9, 65 (2020)
- The interaction of RecA with both CheA and CheW is required for chemotaxis Front. Microbiol. 11, 583 (2020)
- Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions eLife 9, 56418 (2020)
- GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic r Cell. Death. Dis. 11, 62 (2020)
- Identifying crossing collagen fibers in human corneal tissues using pSHG images Biomed. Opt. Express 10, 3875 (2019)
- Enhanced light sheet elastic scattering microscopy by using a supercontinuum laser MPs 2, 57 (2019)
- Comparison of different polarization sensitive second harmonic generation imaging techniques MPs 2, 49 (2019)
- Large-area biomolecule nanopatterns on diblock copolymer surfaces for cell adhesion studies Nanomaterials 9, 579 (2019)
- Nanoscale structure of amyloid-? plaques in Alzheimer’s disease Sci. Rep. 9, 5181 (2019)
- Assessment of tissue-specific multifactor effects in environmental –omics studies of heterogeneous biological samples: Combining hyperspectral image information and chemometrics Talanta 194, 390-398 (2019)
- Effects of near infrared focused laser on the fluorescence of labelled cell membrane Sci. Rep. 8, 17674 (2018)
- Raman spectroscopy quantification of eumelanin subunits in natural unaltered pigments Pigment Cell Melanoma Res. 2018, 1-10 (2018)
- Unravelling the metabolic progression of breast cancer cells to bone metastasis by coupling Raman spectroscopy and a novel use of Mcr-Als algorithm Anal. Chem. 90, 5594-5602 (2018)
- Combining hyperspectral imaging and chemometrics to assess and interpret the effects of environmental stressors on zebrafish eye images at tissue level J. Biophoton. 11, e201870133 (2018) Cover page
- 3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment Biomaterials 163, 185-197 (2018)
- Transcriptome analysis in tissue sectors with contrasting crocins accumulation provides novel insights into apocarotenoid biosynthesis and regulation during chromoplast biogenesis Sci. Rep. 8, 2843 (2018)
- Light-sheet microscopy: a tutorial Adv. Opt. Photon. 10, 111-179 (2018)
- Interference with Clp protease impairs carotenoid accumulation during tomato fruit ripening J. Experimental Botany 69, 1557-1568 (2018)
- Nanopatterns of surface-bound ephrinB1 produce multivalent ligand–receptor interactions that tune EphB2 receptor clustering Nano Lett. 18, 629-637 (2018)
- Synaptic phosphorylated alpha-synuclein in dementia with Lewy bodies Brain 140, 3204-3214 (2017)
- Sub-diffraction discrimination with polarization-resolved two-photon excited fluorescence microscopy Optica 4, 911-918 (2017)
- Relevant aspects of unmixing/resolution analysis for the interpretation of biological vibrational hyperspectral images Trends Anal. Chem. 94, 130-140 (2017)
- Three-dimensional imaging flow cytometry through light-sheet fluorescence microscopys Cytometry Part A, 91A, 144-151 (2017)
- Imaging tissue-mimic with light sheet microscopy: A comparative guideline Sci. Rep. 7, 44939 (2017)
- High-resolution morphological approach to analyse elastic laminae Injuries of the ascending aorta in a murine model of Marfan syndrome Sci. Rep. 7, 1505 (2017)
- STED imaging performance estimation by means of Fourier transform analysis Biomed. Opt. Express 8, 2472-2482 (2017)
- Polarized cortical tension drives zebrafish epiboly movements Embo J. e201694264 (2016)
- Identification of individual exosome-like vesicles by surface enhanced Raman spectroscopy Small 12, 3292-3301 (2016)
- Light-sheet microscopy imaging of a whole cleared rat brain with Thy1-GFP transgene Sci. Rep. 6, 28209 (2016)
- Adaptive optics scanning laser ophthalmoscope imaging: technology update Clin. Ophthalmol. 10, 743-755 (2016)
- Two photon versus one photon fluorescence excitation in whispering gallery mode microresonators J. Lumin. 170, 860-865 (2016)
- Tomato fruit carotenoid biosynthesis is adjusted to actual ripening progression by a light-dependent mechanism Plant J. 85, 107-119 (2016)
- Stochastic optical reconstruction microscopy (STORM) in comparison with stimulated emission depletion (STED) and other imaging methods J. Neurochem. 135, 643-658 (2015)
- Rapid spontaneous Raman light sheet microscopy using cw-lasers and tunable filters Biomed. Opt. Express 6 3449-3461 (2015)
- Decoupled illumination detection in light sheet microscopy for fast volumetric imaging Optica 2, 702-705 (2015)
- Translational label-free nonlinear imaging biomarkers to classify the human corneal microstructure Biomed. Opt. Express 6, 2803-2818 (2015)
- Fast monitoring of in-vivo conformational changes in myosin using single scan polarization-SHG microscopy Biomed. Opt. Express 5, 4362-4373 (2014)
- Dynamic molecular monitoring of retina inflammation by in vivo Raman spectroscopy coupled with multivariate analysis J. Biophoton. 7, 724-734 (2014)
- Two-photon fluorescence imaging with 30 fs laser system tunable around 1 micron Opt. Express 22, 16456-16461 (2014)
- Molecular monitoring of epithelial-to-mesenchymal transition in breast cancer cells by means of Raman spectroscopy Biochim. Biophys. Acta-Mol. Cell Res. 1843, 1785-1795 (2014)
- A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis Mol. Cell. Proteomics 12, 2111-2125 (2013)
- Quantitative imaging of microtubule alteration as an early marker of axonal degeneration after ischemia in neurons Biophys. J. 104, 968-975 (2013)
- Femtosecond laser axotomy in Caenorhabditis elegans and collateral damage assessment using a combination of linear and nonlinear imaging techniques PLoS ONE 8, e58600 (2013)
- The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells J. Biol. Chem. 287, 38946-38955 (2012)
- Effect of molecular organization on the image histograms of polarization SHG microscopy Biomed. Opt. Express 3, 2681-2693 (2012)
- High peak-power picosecond pulse generation at 1.26 µm using a quantum-dot-based external-cavity mode-locked laser and tapered optical amplifier Opt. Express 20, 14308-14320 (2012)
- Image formation by linear and nonlinear digital scanned light-sheet fluorescence microscopy with Gaussian and Bessel beam profiles Biomed. Opt. Express 3, 1492-1505 (2012)
- Molecular engineering of chromophores for combined second-harmonic and two-photon fluorescence in cellular imaging Chem. Sci. 3, 984-995 (2012)
- Measurement and correction of in vivo sample aberrations employing a nonlinear guide-star in two-photon excited fluorescence microscopy Biomed. Opt. Express 2, 3135-3149 (2011)
- Ultrastructural analysis of myocardiocyte sarcomeric changes in relation with cardiac dysfunction in human fetuses with intrauterine growth restriction Am. J. Obstet. Gynecol. 204, S34 (2011) Link to Am. J. Obstet. Gynecol.
- Compact ultrafast semiconductor disk laser: targeting GFP based nonlinear applications in living organisms Biomed. Opt. Express 2, 739-747 (2011) Highlighted in Photonics.com
- Live-cell imaging/femtosecond lasers: ultrafast lasers + thg microscopy = flexible in-vivo cell research OptoIQ 3, 1-3 (2010)
- Third-harmonic generation for the study of Caenorhabditis elegans embryogenesis J. Biomed. Opt. 15, 046020 (2010)
- Fast image analysis in polarization SHG microscopy Opt. Express 18, 17209-17219 (2010)
- Estimating the helical pitch angle of amylopectin in starch using polarization second harmonic generation microscopy J. Opt. 12, 084007 (2010)
- A simple scanless two-photon fluorescence microscope using selective plane illumination Opt. Express 18, 8491-8498 (2010) Highlighted in Virtual Journal for Biomedical Optics
- Signalling effect of NIR pulsed lasers on axonal growth J. Neurosci. Meth. 186, 196-201 (2010) Link to J. Neurosci. Meth.
- Real time imaging of femtosecond laser induced nano-neurosurgery dynamics in C. elegans Opt. Express 18, 364-372 (2010)
- In vivo, pixel-resolution mapping of thick filaments' orientation in nonfibrilar muscle using polarization-sensitive second harmonic generation microscopy
J. Biomed. Opt. 14, 014001 (2009)
Link to J. Biomed. Opt.
Highlighted in Virtual Journal for Biomedical Physics Research - Estimation of the effective orientation of the SHG source in cortical neurons Opt. Express 17, 14418-14425 (2009)
- Multimodal optical workstation for simultaneous linear, nonlinear microscopy and nanomanipulation: Upgrading a commercial confocal inverted microscope Rev. Sci. Instrum. 80, 073701 (2009)
- Myosin helical pitch angle as a quantitative imaging for characterization of cardiac programming in fetal growth restriction measured by Polarization Second Harmonic Microscopy Proc. SPIE 7367, 73670O (2009) Link to Proc. SPIE
- Quantitative discrimination between endogenous SHG sources in mammalian tissue, based on their polarization response Opt. Express 17, 10168-10176 (2009)
- Influence of distant femtosecond laser pulses on growth cone fillopodia Cytotechnology 58, 103-111 (2008) Link to Cytotechnology
- Decrease in laser ablation threshold for epithelial tissue microsurgery in a living Drosophila embryo during dorsal closure J. Microsc. 232, 362-368 (2008) Link to J. Microsc.
- Nonlinear immunofluorescent assay for androgenic hormones based on resonant structures Opt. Express 16, 13315-13322 (2008)
- Starch-based backwards SHG for in situ MEFISTO pulse characterization in multiphoton microscopy J. Microsc. 230, 70-75 (2008)
- Lost writing uncovered by laser two-photon fluorescence provides a terminus post quem for Roman colonization of Hispania Citerior J. Archaeol. Sci. 34, 1594-1600 (2007) Link to J. Archaeol. Sci.
- Archaeophotonics: lasers unveil the past Opt. Photon. News 18 (July/August), 20-25 (2007)
- Cavity resonances in finite plasmonic chains Appl. Phys. Lett. 90, 041109 (2007)
- Simultaneous analytical characterisation of two ultrashort laser pulses using spectrally resolved interferometric correlations Opt. Express 14, 4538 - 4551 (2006)
- Optical Dyakonov surface waves at magnetic interfaces Opt. Lett. 30, 3075-3077 (2005)
- Resonant double grating waveguide structures as enhancement platforms for two-photon fluorescence excitation Appl. Phys. Lett. 87, 081109 (2005)
- Mechanisms of refractive index modification during femtosecond laser writing of waveguides in alkaline lead-oxide silicate glass Appl. Phys. Lett. 87, 021109 (2005)
- Two-photon fluorescence sensors based on resonant grating waveguide structures Sens. Actuators B-Chem. 107, 121-125 (2005)
- Measurement of electric field by interferometric spectral trace observation Opt. Lett. 30, 1063-1065 (2005)
- Starch-based second-harmonic-generated collinear frequency-resolved optical gating pulse characterization at the focal plane of a high-numerical-aperture lens Opt. Lett. 29, 2282-2284 (2004)
- Enhanced two-photon fluorescence excitation by resonant grating waveguide structures Opt. Lett. 29, 1989-1991 (2004)
- Tunable and multiple-wavelengths/temporal output from gain-switched diode laser and a four Bragg-grating Fiber Appl. Phys. Lett. 85, 861-862 (2004)
- Periodically switched nonlinear structures for frequency conversion: theory and experimental demonstration IEEE J. Quantum Electron. 40, 1122-1130 (2004)
- Ultrashort pulse characterisation with SHG collinear-FROG Opt. Express 12, 1169-1178 (2004)
- Proceedings & Book Chapter
- Nonlinear bio-imaging with a high peak power all-quantum-dot master-oscillator power-amplified system CLEO 2012, ATh1M.2 (2012)
- Depth aberrations characterization in linear and nonlinear microscopy schemes using a shack-Hartmann wavefront sensor Proc. SPIE 8227, 82271D (2012)
- Multiphoton imaging with compact semiconductor disk lasers Proc. SPIE 8242, 82420O (2012) Invited
- Portable semiconductor disk laser for in vivo tissue monitoring: a platform for the development of clinical applications Proc. SPIE 8092, 80920R (2011)
- Simultaneous SHG and TPEF imaging using a new type of selective markers Proc. SPIE 8086-46 (2011)
- Imaging amylopectin's order in starch using 3-dimensional polarization SHG Proc. SPIE 8086-21 (2011)
- Open-loop wavefront sensing scheme for specimen aberrations correction in two-photon excited fluorescence microscopy Proc. SPIE 8086, 808603 (2011)
- In-vivo third-harmonic generation microscopy at 1550nm three-dimensional long-term time-lapse studies in living C. elegans embryos Proc. SPIE 7904, 79041G (2011)
- Compact ultrafast semiconductor disk laser for nonlinear imaging in living organisms Proc. SPIE 7903, 79032T (2011)
- Direct aberrations correction in two photon microcopy by a single on-axis measurement Proc. OSA Novel Tech. Microscopy, 1029754 (2011) NWB6
- Three-dimensional polarization second harmonic generation (3D-PSHG) imaging: the effect of the tilted-off the plane SHG active structures Proc. SPIE 7903, 79030H (2011)
- Adaptive optics in sectioning microscopes: the practical implementation Proc. SPIE 7902, 79021A (2011)
- Ultrastructural analysis of the sarcomere in relation with cardiac dysfunction in a rabbit model of intrauterine growth restriction Ultrasound Obst. Gyn. 36, 166 (2010)
- Optical extraction of the helical pitch angle of amylopectin in starch Proc. SPIE 7715, 771529 (2010)
- Assessing structural characteristics of axons in cortical neurons using polarization sensitive SHG Proc. SPIE 7715, 77152A (2010)
- Practical optical quality assessment and correction of a nonlinear microscope Proc. SPIE 7570, 75700W (2010)
- Polarization second harmonic generation (PSHG) imaging of neurons: estimating the effective orientation of the SHG source in axons Proc. SPIE 7569, 75692W (2010)
- Contrast enhancement in second harmonic imaging: discriminating between muscle and collagen Proc. SPIE 7367, 73670S (2009)
- Two photon fluorescence spectroscopy based on resonant grating waveguide structures Proc. SPIE Int. Soc. Opt. Eng. 5840, 254 (2005)
- Solid-liquid crystal interfaces probed by optical second-harmonic generation in Surfaces and Interfaces of Liquid Crystals, eds. Th. Rasing, I. Musevic (Springer, Germany, 2004)
- Articles in Magazines
- Decoding the code of life Optics & Photonics Focus 6, 3 (2009)
- Neurosurgery goes nano inside a chip Optics & Photonics Focus 3, 5 (2008)
- Cells in the heart dance to the tune of light Optics & Photonics Focus 2, 2 (2008)
- Invited Talks
- FAST-DOT Latin Laser Lab Meeting, Salamanca, Spain, March 5-6, 2012
- Presentation of STELUM project: Industry-academy teaming up to push the limits of multiphoton microscopy Bio Light for Health program, ICFO, Barcelona, Spain, May 30-31, 2011
- Talks
- How do cells sense physical forces? Cellular mechanosensing and motility in biomimetic 3D environments Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP), Madrid, Spain, July 2019
- Mechanosensitive actomyosin network dynamics and migration plasticity in 3D environments Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP), Madrid, Spain, July 2019
- SIMPLE: Structured illumination localization microscopy Joint 12th EBSA European Biophysics Congress / 10th IUPAP International Conference on Biological Physics (ICBP), Madrid, Spain, July 2019
- Ultrashort-pulsed chip-sized lasers for two-photon excited fluorescence imaging Focus on Microscopy, Singapore, April 1-4, 2012 Paper P1-D13
- The nonlinear guide-star concept: A fast and noninvasive method to measure and correct sample induced aberrations Focus on Microscopy, Singapore, April 1-4, 2012 Paper P1-D13
- Polarization SHG imaging of nonlinear dyes Focus on Microscopy, Konstanz, Germany, April 17-20, 2011
- Efficient nonlinear excitation of encoded fluorescent proteins in living samples using a semiconductor disk laser Focus on Microscopy, Konstanz Germany, April 17-20, 2011 Paper 39
- In vivo third harmonic generation microscopy at 1550nm: Morphogenesis studies in living Caenorhabditis elegans embryos BioPhotonics and Imaging Conference, (BioPIC 2010), Meath, Ireland, October 18-20, 2010 Paper C8
- Cell division stage in C. elegans imaged using third harmonic generation microscopy BIOMED, Miami, United States, April 2010
- Discrimination between collagen and muscle using polarization second harmonic imaging with pixel resolution Focus On Microscopy Conference Series, FOM 2009, Krakow, Poland, April 5-8, 2009
- Complete optical quality analysis of a non-linear microscope Focus on Microscopy Conference Series, FOM 2009, Krakow, Poland, April 5-8, 2009
- Polarization sensitive second-harmonic generation in nonlinear microcopy Hot topics in molecular imaging 2009, TOPIM’09, Les Houches, France, January 26-30, 2009
- Mean effective orientation of the source molecules in second harmonic imaging microscopy of collagen and muscle Scientific Meeting of the Network of Excellence Photonics4life, Brussels, Belgium, November 18-19, 2008
- Mean effective orientation of the source molecules in second harmonic imaging microscopy of collagen and muscle LASERLAB Foresight Workshop and Users Meeting “Trends of Laser Applications in Biology and Biomedicine”, Heraklion, Crete, Greece, October 23-24, 2008
- Polarization dependant in vivo second harmonic generation imaging of Caenorhabditis elegans vulval, pharynx and body wall muscles Multiphoton Microscopy in the Biomedical Sciences VIII., Proceedings of the SPIE 6860, 686008-686008-10 (2008)
- Starch granules as a probe for the polarization at the sample plane of a high resolution multiphoton microscope Multiphoton Microscopy in the Biomedical Sciences VIII., Proceedings of the SPIE 6860, 68600E- 68600E-11 (2008)
- In vivo Second Harmonic Generation (SHG) imaging of C. elegans muscles using ultra-short laser pulses European Worm (C. elegans) meeting - (EWM 2008), Carmona (Seville), Spain, March 29th-April 2nd, 2008
- Polarization sensitive second harmonic generation imaging for pixel resolution mapping of thick filaments in living C. elegans European Laboratory for Non-linear Spectroscopy – (LENS), Florence, Italy, 23-26 April, 2008
- Investigation of ultrashort pulse dispersion through a non-linear microscope CLEO/Europe-EQEC, Munich, Germany, June 2005
- Simple experimental technique for analytically characterizing ultrashort laser pulses CLEO/Europe-EQEC, Munich, Germany, June 2005
- The use of a spectrally resolved interferometric correlation to analytically determine the phase of two unknown ultrashort laser pulses CLEO/Europe-EQEC, Munich, Germany, June 2005
- MEFISTO: measuring the electric field of ultrashort pulses by interferometric spectral trace observation CLEO/ IQEC 2005, Baltimore, USA, May 2005
- Simoultaneous analytical characterisation of two unknown ultrashort laser pulses: blind-MEFISTO CLEO/ IQEC 2005, Baltimore, USA, May 2005
- Two-photon fluorescence spectroscopy by resonant single and double grating waveguide structures CLEO/QELS 2005, Baltimore, USA, May 2005
- Two-photon fluorescence spectroscopy based on resonant grating waveguide structures Microtechnologies for new millennium, Sevilla, Spain, May 2005
- Two-photon fluorescence spectroscopy by resonant grating waveguide structures 2nd Nanospain Workshop, Auditorium Sant Joan de Deu, Barcelona, March 2005
- Starch solutions based SHG-FROG pulse characterisation in a nonlinear microscope CLEO/ IQEC 2004, San Francisco, USA, May 2004
- Enhanced two-photon fluorescence excitation by resonant waveguide structures CLEO/ IQEC 2004, San Francisco, USA, May 2004
- Nonlinear microscopy pulse optimization at the sample plane using second-harmonic generation from starch Photonics Europe (SPIE), Strasbourg, France, April 2004
- Ferroelectric phase transitions and electroclinic effect in thin cells of chiral smectic liquid crystals ECOSS 2003, Prague, Czech Republic, September 2003
- Ferroelectric ordering and electroclinic effect in thin liquid crystal cells studied by linear and nonlinear optics Optical Science and Technology, SPIE’s 48th Annual Meeting, San Diego, USA, August 2003
- Posters
- Portable ultrafast semiconductor disc laser for nonlinear bio-imaging applications ICFO Corporate Liaison Program, Barcelona, Spain, November 14, 2011 Paper 02
- STELUM - Spatio-temporal engineering of Light. Ultimate Multiphoton Microscopy Europhotonics Spring School, Casteldefells, Barcelona, March 31, 2012
- STELUM - Spatio-temporal engineering of Light. Ultimate Multiphoton Microscopy Marie Curie Event, Warsaw, Poland, November 18-19, 2011 Paper YH-7
- Compact ultrafast semiconductor disk laser for nonlinear imaging in living organisms Light for Health, Barcelona, Spain, May 30-31, 2011 Paper 002
- New technique for aberration measurement and correction in TPEF microscopy Light for Health, Barcelona, Spain, May 30-31, 2011 Paper 001
- In vivo recordings of morphogenesis in C. elegans embryos using non-invasive Third Harmonic Generation microscopy Photonics 4 Life, Paris, France, November 2010 Paper. P02 (2010).
- In vivo recordings of morphogenesis in C. elegans embryos using non-invasive Third Harmonic Generation microscopy European Molecular Biology Organization (EMBO), Barcelona, Spain, September 4-7, 2010 Paper C-196
- Optical análisis and aberration correction in a nonlinear microscope OPTOEL, Málaga, Spain, July 2009 Paper STD-5
- New technique for aberration measurement and correction in TPEF microscopy Photonics 4 Life, Florence, Italy, 2009
- Enhanced two-photon fluorescence excitation by resonant waveguide structures CLEO/ IQEC 2004, San Francisco, USA, May 2004
- Two photon fluorescence sensor based on resonant grating waveguide structures Europt(r)ode VII, Madrid, Spain
- Ferroelectric ordering and electroclinic effect in thin liquid crystal cells studied by linear and nonlinear optics Optical Science and Technology, SPIE’s 48th Annual Meeting, San Diego, USA, August 2003
- Masters Theses
- Fibres òptiques per al control de polsos ultracurts en aplicacions de fluorescència no lineal
- Recuperación de escritura pintada sobre piezas arqueológicas mediante fluorescencia no lineal
- Caracterización de pulsos de luz láser ultracortos
- Propagació de polsos òptics ultracurts en cristalls fotònics
- PhD Theses
- Development of novel imaging tools for selected biomedical applications
- Ultrashort laser pulse measurement for multiphoton microscopy
- Strategies for pushing nonlinear microscopy towards its performance limits
- Neuron guidance and nano neuro-surgery using optical tools
- Applications of two-photon fluorescence in biology and immunosensing
- Optimización de las prestaciones de enlaces ópticos submarinos de gran capacidad y larga distancia mediante el control de la dispersión
SLN - Team Loza
Dr. Pablo Loza-Alvarez

- 2020-10-16 When feeling the pinch, nuclei instigate cells to escape crowded spaces Scientists from CRG, ICFO, FH OÖ and UPF report on this new finding in a study published in the journal Science.
- 2020-09-21 Institut de Recerca Sant Joan de Déu and ICFO create a joint lab to improve neonatal and paediatric health care The new joint laboratory will advance the use and development of photonic technologies to understand, diagnose, monitor and treat paediatric diseases.
- 2019-09-16 “la Caixa” Health Research Grant allows BIST researchers to advance graphene-based retinal prosthesis research ICFO participates in the i-VISION project consortium with ICN2, IFAE, Barraquer Foundation and Institut de Vision (University of Sorbonne)
- 2019-07-17 FET Launchpad funding awarded to MESO-BRAIN partners ICFO receives funding to continue breakthrough technology for developing new imaging technology
- 2019-02-01 BIST IGNITE Call Awardees ICFO participates in three multidisciplinary research projects awarded second round funding in this BIST call
- 2018-04-05 2017 BIST Ignite Awards ICFO will participate in multidisciplinary research projects funded through the 2017 Ignite Awards.
- 2018-02-09 ICFO member of the MERLIN Project ICFO participates in the MERLIN project, aimed to deliver breakthrough medical technology to image the back of the eye.
- 2018-01-17 IGNITE CALL Awardees ICFO participates in one of three multidisciplinary projects funded in the Ignite Program’s second phase.
- 2017-10-09 ICFO becomes a new LEICA NANOSCOPY IMAGING REFERENCE SITE in Europe Leica Microsystems and ICFO sign an R&D collaboration agreement
- 2016-06-09 MESO-BRAIN and light sheet imaging techniques MESO-BRAIN initiative receives €3.3million to replicate brain’s neural networks through 3D nanoprinting.
- 2016-02-10 Euro‐BioImaging research Infrastructures The SLN at ICFO ratified as a first generation Euro-BioImaging node
- 2015-12-17 Photonics and Tomatoes The SLN facility at ICFO collaborates with CRAG to analyze the ripening process of tomatoes.
- 2015-12-02 Three ICFO studies in “Optics in 2015” The Optics & Photonics Magazine highlights 3 ICFO studies in its OPN Year selection
- 2015-01-09 New RETOS industrial projects at ICFO Two ICFO research groups take on industrial projects with FYLA and Signadyne
- 2014-11-12 TV3 Foundation’s La Marató to fight Neurodegenerative diseases ICFO awarded funding to participate in two projects in this year’s call.
- 2014-10-09 1st LSFM International Conference 1st LightSheet Fluorescence Microscopy International Conference & 6th LSFM International Workshop
- 2014-10-01 Monitoring Retinal Inflammation by Raman Spectroscopy Journal of Biophotonics highlights ICFO study.
- 2014-09-10 NIH Grant for Breast Cancer Research ICFO receives NIH Grant to study breast cancer through an innovative technique.
- 2013-06-28 Congratulations to new ICFO PhD Graduate Dr. Iván Amat Roldán graduated with a thesis on developing the precise aspect of ultrashort laser pulse measurement in the context of biomedical research.
- 2013-03-27 Congratulations to new ICFO PhD graduate Dr. Rodrigo Avilés graduates with a thesis on maximizing the performance of nonlinear microscopy.
- 2013-03-14 Laser dissection of neurons ICFO researchers present a new technique on laser dissection of neurons in PLOS ONE.
- 2012-04-19 ICFO in Chemical Science A collaboration between KU Leuven and the group led by Prof. Loza-Alvarez on the cover of Chemical Science.
- 2012-02-24 SPIE Photonics West 2012 Poster Award A collaboration between KU Leuven and the Super-resolution Light Nanoscopy facility at ICFO awarded at BiOS conference.
- 2010-11-29 BioPic 2010 Award Research at the group led by Prof. Pablo Loza-Alvarez, awarded with the first prize in the BioPic 2010 PhD poster session.
- 2010-04-19 Image of the Week Optics InfoBase highlights an image obtained in the group led by ICFO Prof. Pablo Loza-Alvarez.
- 2009-11-27 New ICFO PhD Graduate Dr. Manoj Mathew obtained his Doctoral Degree with a thesis on optical manipulation of neurons supervised by Prof. Pablo Loza-Alvarez.
- 2009-11-09 Photonics 4 Life at ICFO Third Scientific Meeting of Photonics for Life Network of Excellence.
- 2009-10-23 New ICFO PhD Graduate Dr. Anisha Thayil obtained her Doctoral Degree with a project on applications of two-photon fluorescence in biology co-supervised by Prof. Pablo Loza-Alvarez and Dr. Silvia Soria.
- 2009-04-02 ICFO Congratulates a New PhD Graduate Dr. Petru Ghenuche obtained his Doctoral Degree with a project on probing the near-field optical response of plasmon nanostructures with two-photon luminescence microscopy supervised by Prof. Romain Quidant and co-directed by Prof. Gonçal Badenes.
- 2009-04-02 PhD Thesis Defense
PETRU GHENUCHE \'Probing the near-field optical response of plasmon nanostructures with two-photon luminescence microscopy\' PETRU GHENUCHE
Nano-photonics
ICFO-The Institute of Photonic Sciences
SPAIN - 2009-03-16 Enlightening C. elegans A workshop on advanced imaging of the C. elegans will take place at ICFO on March, 26th.
- 2008-11-08 ICFO Incubator Welcomes COSINGO Start-up COSINGO establishes itself at ICFO incubation space.
- 2008-09-03 New Generation of Multi-photon Imaging Systems Imagine Optic and ICFO join forces to build an ultra-sharp multi-photon imaging system.
- 2008-03-17 ICFO in Catalonia Today An article features the research by Pablo Loza\'s group on neuron guiding by laser light.
- 2008-02-19 ICFO in El País Research by Prof. Pablo Loza\'s group on neuron guiding by laser light is the topic of a feature in the national newspaper.
- 2007-06-29 Archaeophotonics in Optics and Photonics News ICFO researchers use two-photon fluorescence to recover written information on roman relics and solve a 2000-year-old mystery.
- 2007-05-15 The MIT Technology Review highlights ICFO research The prestigious magazine features an article about Spain’s Biotech activities
- 2005-12-19 ICFO congratulates a new PhD graduate Dr Emilio Gualda Manzano obtained his Dr Ing degree with a research project on the optimization of the performance of long-haul high capacity submarine optical fiber links, supervised by Prof. Juan P. Torres.
- 2005-05-25 ICFO students make it to the final of the OSA- New Focus/Bookham Student Award 2005 Ivan Amat amongst the seven best students in Photonics for his work on ultrashort laser pulses for biological applications
- 2004-07-22 OLE Magazine echoes about an innovative technique in ultrashort pulses performed by ICFO researchers The research is carried out by Pablo Loza\'s group